LYSOSOMAL ACID LIPASE DEFICIENCY: A RARE INHERITED DYSLIPIDEMIA BUT POTENTIAL UBIQUITOUS FACTOR IN THE DEVELOPMENT OF ATHEROSCLEROSIS AND FATTY LIVER DISEASE

Lysosomal acid lipase deficiency: A rare inherited dyslipidemia but potential ubiquitous factor in the development of atherosclerosis and fatty liver disease

Lysosomal acid lipase (LAL), encoded Oven Kick Panel by the gene LIPA, is the sole neutral lipid hydrolase in lysosomes, responsible for cleavage of cholesteryl esters and triglycerides into their component parts.Inherited forms of complete (Wolman Disease, WD) or partial LAL deficiency (cholesteryl ester storage disease, CESD) are fortunately rare

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Microbiome diversity and metabolic capacity determines the trophic ecology of the holobiont in Caribbean sponges

Abstract Sponges are increasingly recognized as an ecologically important taxon on coral reefs, representing significant biomass and biodiversity where sponges have replaced scleractinian corals.Most sponge species can be divided into two symbiotic states based Purse Charm on symbiont community structure and abundance (i.e., the microbiome), and ar

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Secure asset transaction using blockchain

The current property exchange methodology includes a lot of susceptibilities and people use it to delude the common people and the government.Using blockchain, this project utilises majority Oven Kick Panel consensus to implement secure asset transactions.The main objective behind the implementation of asset transaction using blockchain is to secur

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Single-molecule FRET unmasks structural subpopulations and crucial molecular events during FUS low-complexity domain phase separation

Abstract Biomolecular condensates formed via phase separation of proteins and nucleic acids are thought to be associated with a wide range of cellular functions and dysfunctions.We dissect critical molecular events associated with phase separation of an intrinsically disordered prion-like low-complexity domain of Fused in Sarcoma by performing sing

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